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Neuroimaging Clin. N. Am. · Nov 2017
ReviewMethods and Considerations for Dynamic Analysis of Functional MR Imaging Data.
- Jingyuan E Chen, Mikail Rubinov, and Catie Chang.
- Department of Radiology, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, 1201 Welch Road, Stanford, CA 94305, USA.
- Neuroimaging Clin. N. Am. 2017 Nov 1; 27 (4): 547560547-560.
AbstractFunctional MR imaging (fMR imaging) studies have recently begun to examine spontaneous changes in interregional interactions (functional connectivity) over seconds to minutes, and their relation to natural shifts in cognitive and physiologic states. This practice opens the potential for uncovering structured, transient configurations of coordinated brain activity whose features may provide novel cognitive and clinical biomarkers. However, analysis of these time-varying phenomena requires careful differentiation between neural and nonneural contributions to the fMR imaging signal and thorough validation and statistical testing. In this article, the authors present an overview of methodological and interpretational considerations in this emerging field.Published by Elsevier Inc.
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