• Robert Taylor, Tong J Gan, Robert B Raffa, Chris Gharibo, Marco Pappagallo, Nicholas R Sinclair, Charles Fleischer, and Aaron Tabor.
• NEMA Research, Naples, FL, USA. robert.taylor.phd@gmail.com
• Pain Pract. 2012 Nov 1;12(8):610-9.

BackgroundTopical analgesics are important products in the armamentarium for pain relief.Methods And FindingsThis study compared a topical analgesic product containing menthol to the same product with the addition of oxygenated glycerol triesters (OGTs) (also called essential oxygen oil) in 66 healthy adult subjects with acute musculoskeletal pain. Patients were randomized in a single-center, double-blind study to receive mentholated cream (MC) only or MC containing OGTs. Patients self-reported their pain intensity, lifestyle limitations, and evaluation of the mobility of the painful joint or muscle at baseline and three times daily over a seven-day course on a 100-mm visual analog scale (VAS). Patients in both groups experienced statistically significant pain relief on Day 8 over baseline, with the MC plus OGT-treated group reporting statistically significantly greater pain relief than the MC group (P = 0.016). In addition, patients treated with the combination product experienced an incremental decrease in pain during each of the 7 days of treatment in addition, and they had lower VAS scores and greater lifestyle and mobility improvements than the MC group. Both products were well tolerated with no serious adverse events reported and no signs of significant skin reactions in either group.ConclusionBased on this study, a MC containing OGTs is safe, effective, and provided significantly better pain relief than MC alone. The combination of oxygenated glycerol trimesters and MC provided significant pain relief and offered continued improvement in pain relief over time.© 2012 The Authors. Pain Practice © 2012 World Institute of Pain.

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