• Journal of biophotonics · Jan 2010

    Quantified characterization of human cutaneous normal scar using multiphoton microscopy.

    • Xiaoqin Zhu, Shuangmu Zhuo, Liqin Zheng, Kecheng Lu, Xingshan Jiang, Jianxin Chen, and Bifang Lin.
    • Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou, P.R. China.
    • J Biophotonics. 2010 Jan 1; 3 (1-2): 108-16.

    AbstractThe morphological alterations of human cutaneous normal scar were quantitatively analyzed using multiphoton microscopy (MPM) based on two-photon excited fluorescence and second harmonic generation. High-contrast, high-resolution images of normal scar and uninjured skin were obtained for comparison. In addition, some quantitative parameters have been extracted to quantitatively discriminate between normal scar and uninjured skin. The MPM combined with quantitative method enable a better understanding of microstructual alterations of the epidermis, elastic fiber, and collagen in normal scar. It may lead the way to making know the mechanism of normal scar formation and identifying feasible therapeutic options.2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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