• Christopher Sy, James Henry, Bhavani Kura, Andrew Brenner, and Ramesh Grandhi.
• Department of Neurosurgery, University of Texas Health San Antonio, San Antonio, Texas, USA. Electronic address: sy@uthscsa.edu.
• World Neurosurg. 2018 Jan 1; 109: 342-346.

BackgroundRubinstein-Taybi syndrome (RSTS) is a rare, congenital syndrome that is known to be associated with neoplasms of various organ systems. Evaluation and treatment of such patients is challenging, given the cognitive delay and heterogeneity of pathologic presentations that define this syndrome.Case DescriptionPresented here is a case of a patient with RSTS, diagnosed at birth, who presented with subtle symptoms of lethargy and a change in behavior. He was found to have a large (7.0-cm × 4.7-cm), right-sided brain mass that was eventually diagnosed as a primary central nervous system lymphoma.ConclusionsTo the best of our knowledge, this is the first reported case of a primary central nervous system lymphoma presenting in a patient with RSTS. This was confirmed through microscopic and histologic studies. The large size attained by this mass in our patient highlights the increased scrutiny and surveillance needed to provide the best care for these patients. A multidisciplinary team approach is ideal as successful treatment of our patient using surgical debulking, appropriate chemotherapy, and close postoperative follow-up has resulted in an excellent clinical outcome.Copyright © 2017 Elsevier Inc. All rights reserved.

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