• Mohammad Zandi, Arash Dehghan, Payam Amini, Leila Rezaeian, and Shideh Doulati.
• Department of Oral and Maxillofacial Surgery, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: zandi88m@yahoo.com.
• Injury. 2017 Dec 1; 48 (12): 2683-2687.

IntroductionTo evaluate fracture healing in mandible of rats under zoledronate therapy.MethodsA total of 135 Wistar rats were randomly allocated into 3 groups. Group L received two intravenous infusion of 0.06 mg/kg zoledronate 6 weeks apart. Group H received the same dose of zoledronate as group L once a week for 6 weeks and group C were treated with normal saline. Seven days after the last infusion, rats underwent unilateral mandibular osteotomy to replicate a fracture. Fifteen rats from each group were sacrificed 2, 4, and 6 weeks after surgery. Fracture calluses were examined and scored using a histological grading system (1 to 10).ResultsAfter 2 weeks, substantial woven bone and some lamellar bone were seen in control and L groups. In group H, healing was delayed and consisted of fibrous and cartilaginous tissue and some woven bone. After 4 weeks, most of woven bone in control group was replaced with lamellar bone but in group L, comparatively less bone remodeling occurred. In group H, healing process was nearly the same as that at 2 weeks. After 6 weeks, complete bone remodeling was seen in control group. In group L, bone remodeling was under way and in group H, histological findings were nearly the same as those at 2 and 4 weeks. Except for L and control groups at 2 weeks, healing score was significantly different between all corresponding groups.ConclusionZoledronate therapy delayed healing process of mandibular fracture in rats in a dose-dependent manner.Copyright © 2017 Elsevier Ltd. All rights reserved.

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