• A A romanovskaia, T N I'icheva, A G Durymanov, M B Ignashkina, K A Sharshov, I M Susloparov, E M Malkova, E A Stavskiĭ, A M Shestopalov, V T Smirnov, N N Zhukova, I I Pavlova, T Iu Nekhriuk, T P Panamareva, and I G Drozdov.
• Zh. Mikrobiol. Epidemiol. Immunobiol. 2011 Jan 1 (1): 35-9.

AimIsolation and study of molecular genetic characteristics of pandemic influenza virus A (H1N1) circulated in Amur region in autumn 2009 as well as testing of serum samples taken from citizens of this region during November- December 2009 in order to measure levels of antibodies to socially significant serotypes of influenza A virus.Materials And MethodsStrain of pandemic influenza virus A/Blagoveschensk/01/2009 (H1N1) was isolated on MDCK cell culture and nucleotide sequences of all eight segments of viral genome were determined. Five hundred seventy-six serum samples taken in Amur region in autumn 2009 were tested by hemagglutination inhibition assay.ResultsNucleotide sequence of A/Blagovechensk/01/2009 (H1N1) strain was 99.7% identical to reference influenza virus strain A/California/04/2009. Diagnostically significant titers of antibodies to pandemic influenza virus were observed in 46.3% of persons younger 30 years old and in 20.1% older persons. Antibodies to seasonal influenza virus H1N1 and H3N2 were detected in 39.5 and 29.8% of persons respectively.ConclusionFinal seroepidemiological picture of distribution of pandemic virus in Amur region matches with the one for seasonal influenza virus A (H1N1): > 60% of seropositive persons were registered in age group < 18 years old, and this proportion increases with increasing age.

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