• Hergen Buscher, David Zhang, and Priya Nair.
• Intensive Care Unit, St Vincent's Hospital, Sydney, NSW, Australia. hergen.buscher@svha.org.au.
• Crit Care Resusc. 2017 Oct 1; 19 (Suppl 1): 29-36.

ObjectivesMinimal evidence to guide haemostatic therapy for bleeding in extracorporeal life support (ECLS) has resulted in wide variability in practice. We aimed to show that a goal-directed algorithm incorporating results from thromboelastometry (TEM) is feasible and safe for the timely management of bleeding episodes in adult patients receiving ECLS.Design And ParticipantsA pilot randomised controlled trial involving 16 adult patients who underwent ECLS, randomised over 10 months.InterventionThe intervention group was treated according to a goal-directed algorithm based on TEM results during bleeding episodes. Apart from the intervention, both groups received standard care including conventional laboratory coagulation tests.Outcome MeasuresNeed for blood product transfusion, haemorrhagic and thromboembolic complications and survival.ResultsThere was a statistically non-significant trend towards reduction in the amount of blood products transfused, occurrence of bleeding, and thrombotic complications, when comparing the intervention arm with the control arm. Survival to hospital discharge was 69%. A significant correlation was found between fibrinogen levels and FIBTEM clot firmness at 10 minutes (R = 0.812; P < 0.001); activated partial thromboplastin time and clotting time HEPTEM/INTEM ratio (R = -0.719; P < 0.001); and platelet count and EXTEM clot firmness at 10 minutes (R = 0.783; P < 0.001).ConclusionTEM allows assessment for coagulation status in a timely manner and its use for the treatment of bleeding episodes in adult patients receiving ECLS appears feasible and safe. Clinical benefit should be investigated in larger multicentre randomised trials.

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