• World Neurosurg · Feb 2018

    Case Reports

    Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment of ocular surface disease following skull base tumor resection.

    • Carolyn E Kloek, Karen W Jeng-Miller, Deborah S Jacobs, and Ian F Dunn.
    • Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. Electronic address: Carolyn_Kloek@meei.harvard.edu.
    • World Neurosurg. 2018 Feb 1; 110: e124-e128.

    BackgroundProsthetic replacement of the ocular surface ecosystem (PROSE) treatment is an effective, nonsurgical therapeutic option for patients with ocular surface disease related to cranial nerve deficits secondary to skull base tumor resection.MethodsThis case series describes the impact of PROSE treatment in patients with symptomatic exposure keratopathy or neurotrophic keratitis after skull base tumor surgery.ResultsAll patients improved symptomatically and functionally with PROSE treatment, and have had sustained improvement for as long as 3 years.ConclusionsIn postneurosurgical cases in which neurologic function may recover, PROSE treatment offers a safe, nonsurgical treatment option to support the ocular surface during the period of observation awaiting neurologic recovery.Copyright © 2017 Elsevier Inc. All rights reserved.

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