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- Rebecca L Bromley, Jennifer Weston, and Anthony G Marson.
- Division of Evolution and Genomic Science, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, England.
- JAMA. 2017 Nov 7; 318 (17): 1700-1701.
Clinical QuestionIs maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?Bottom LineCertain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.93% in 2565 pregnancies) compared with the offspring of women without epilepsy (2.51% in 2154 pregnancies).
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