• Halil Can, Aydın Aydoseli, Cengiz Gömleksiz, Burcu Göker, Muhittin Emre Altunrende, Müge Dolgun, and Altay Sencer.
• Department of Neurosurgery, Liv Hospital, İstanbul-Turkey. burcugoker79@yahoo.com.
• Ulus Travma Acil Cer. 2017 Jan 1; 23 (6): 452-458.

BackgroundWe investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury.MethodsIn our study, 45 healthy male Sprague Dawley rats were used. Spinal trauma was induced by the clip compression technique via thoracal 7, 8, 9 laminectomies. After inducing the trauma, the drug was continuously administered intraperitoneally for 5 days. After inducing the trauma, the subjects were assessed using Tarlov's motor grading scale and inclined plane test. Five days after the trauma, the spinal cord specimens were harvested, and a histopathological examination was performed.ResultsCompared with the other groups, a statistically significant difference with regard to better results for necrosis, inflammation, and apoptosis was observed in the riluzole only and combination groups. Statistically better motor function scores were observed in the Q-VD-OPh only group than in the other groups.ConclusionWith regard to limiting secondary damage after trauma, statistically significant results were observed in the Q-VDOPh only and Q-VD-OPh-riluzole combination groups. More extensive laboratory studies are required to limit and control the effects of secondary damage after spinal cord trauma.

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