• Neuroimaging Clin. N. Am. · Feb 2018

    Review

    Functional MR Imaging: Blood Oxygen Level-Dependent and Resting State Techniques in Mild Traumatic Brain Injury.

    • Scott Rosenthal, Matthew Gray, Hudaisa Fatima, Haris I Sair, and Christopher T Whitlow.
    • Radiology Informatics and Image Processing Laboratory (RIIPL), Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA; Division of Neuroradiology, Department of Radiology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
    • Neuroimaging Clin. N. Am. 2018 Feb 1; 28 (1): 107-115.

    AbstractThis article discusses mild traumatic brain injury (mTBI)-associated effects on brain functional connectivity assessed via resting-state functional MR (fMR) imaging. Several studies have reported acute post-injury default mode network hyperconnectivity, followed by a period of decreased connectivity before later connectivity normalization in some patients. Other studies have reported mTBI associated effects on connectivity that remain evident for up to 5-years or more. Discordance in the published literature regarding the direction of network connectivity changes (eg, increased versus decreased connectivity) may reflect differences in timing of data collection post-injury, as well as the need to standardize MR imaging acquisition protocols and processing methods.Copyright © 2017 Elsevier Inc. All rights reserved.

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