• Critical care clinics · Jan 2018

    Review

    Biomarkers in Sepsis.

    • Tjitske S R van Engelen, Willem Joost Wiersinga, Brendon P Scicluna, and Tom van der Poll.
    • Division of Laboratory Specialties, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands. Electronic address: t.s.vanengelen@amc.uva.nl.
    • Crit Care Clin. 2018 Jan 1; 34 (1): 139-152.

    AbstractA biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine the causative pathogen), of prognostic value (assigning risk profiles and predict outcome), and in the future may be of theranostic value (aid in selection and monitoring of therapy). Systems biology provides a promising tool for the discovery of novel biomarkers. Biomarkers can be the key to personalized targeted treatment in the future clinical management of sepsis.Copyright © 2017 Elsevier Inc. All rights reserved.

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