• Critical care clinics · Jan 2018

    Review

    Novel Interventions: What's New and the Future.

    • Jean-Louis Vincent and David Grimaldi.
    • Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, Brussels 1070, Belgium. Electronic address: jlvincent@intensive.org.
    • Crit Care Clin. 2018 Jan 1; 34 (1): 161-173.

    AbstractDespite decades of sepsis research, no specific therapies for sepsis have emerged and current management still relies on source control, antibiotics, and organ support. With improved understanding of sepsis pathophysiology and the development of new techniques to enable better characterization of patients with sepsis, clinical trials are beginning to better target new interventions at those patients most likely to respond. This article discusses advances in sepsis therapeutics designed to improve endothelial cell function, purify the blood to help restore immune homeostasis, and provide immunostimulation for patients with immune exhaustion.Copyright © 2017 Elsevier Inc. All rights reserved.

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