• Critical care clinics · Jan 2018

    Review

    Mechanisms of Organ Dysfunction in Sepsis.

    • Rachel Pool, Hernando Gomez, and John A Kellum.
    • Department of Anesthesiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA.
    • Crit Care Clin. 2018 Jan 1; 34 (1): 63-80.

    AbstractSepsis-associated organ dysfunction involves multiple responses to inflammation, including endothelial and microvascular dysfunction, immune and autonomic dysregulation, and cellular metabolic reprogramming. The effect of targeting these mechanistic pathways on short- and long-term outcomes depends highly on the timing of therapeutic intervention. Furthermore, there is a need to understand the adaptive or maladaptive character of these mechanisms, to discover phase-specific biomarkers to guide therapy, and to conceptualize these mechanisms in terms of resistance and tolerance.Copyright © 2017 Elsevier Inc. All rights reserved.

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