• Neuropeptides · Apr 2014

    Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences.

    • Martin O Job, Joanna Perry, Li L Shen, and Michael J Kuhar.
    • Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd. NE, Atlanta, GA 30329, USA. Electronic address: femijob@gmail.com.
    • Neuropeptides. 2014 Apr 1; 48 (2): 75-81.

    AbstractCocaine-and-Amphetamine Regulated Transcript peptide (CART peptide) is known for having an inhibitory effect on dopamine (DA)- and cocaine-mediated actions and is postulated to be a homeostatic, regulatory factor in the nucleus accumbens (NAc). Some sex differences in cocaine-mediated locomotor activity (LMA) and in the expression and function of CART peptide have been reported. However, it is not known if the inhibitory effect of CART peptide on cocaine-mediated LMA is sexually dimorphic. In this study, the effects of CART 55-102 on LMA due to intra-NAc DA and i.p. cocaine were determined in male and female Sprague-Dawley rats. The results show that CART 55-102 blunted or reduced both the DA- and cocaine-induced LMA in both males and females. In conclusion, CART peptide is effective in blunting DA- and cocaine-mediated LMA in both males and females.Copyright © 2014 Elsevier Ltd. All rights reserved.

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