• Neurobiology of aging · Dec 2015

    Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging.

    • Anders M Fjell, Markus H Sneve, Håkon Grydeland, Andreas B Storsve, Ann-Marie Glasø de Lange, Inge K Amlien, Ole J Røgeberg, and Kristine B Walhovd.
    • Research Group for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo, Oslo, Norway; Department of Physical medicine and rehabilitation, Unit of Neuropsychology, Oslo Uni... more versity Hospital, Oslo, Norway. Electronic address: andersmf@psykologi.uio.no. less
    • Neurobiol. Aging. 2015 Dec 1; 36 (12): 3255-3268.

    AbstractA major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state functional connectivity (rsFC) could be a mechanism accounting for reduced function. We addressed this through 3 studies. In study 1, 119 healthy participants (20-83 years) were followed for 3.5 years with verbal recall testing and magnetic resonance imaging. Independent of atrophy, recall change was related to change in rsFC in anatomically widespread areas. Striking age-effects were observed in that a positive relationship between rsFC and memory characterized older participants while a negative relationship was seen among the younger and middle-aged. This suggests that cognitive consequences of rsFC change are not stable across age. In study 2 and 3, the age-dependent differences in rsFC-memory relationship were replicated by use of a simulation model (study 2) and by a cross-sectional experimental recognition memory task (study 3). In conclusion, memory changes were related to altered rsFC in an age-dependent manner, and future research needs to detail the mechanisms behind age-varying relationships.Copyright © 2015 Elsevier Inc. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        

    hide…

What will the 'Medical Journal of You' look like?

Start your free 21 day trial now.

We guarantee your privacy. Your email address will not be shared.