• P Barbanti, G Fabbrini, C Aurilia, N Vanacore, and G Cruccu.
• Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele, Via della Pisana 235, 00163 Rome, Italy. piero.barbanti@sanraffaele.it
• Cephalalgia. 2007 Oct 1; 27 (10): 1115-9.

AbstractMigraine patients often complain of sleepiness, a problem that manifests both during and outside an attack, may impair the quality of life and can lead to potentially harmful situations. Findings from an uncontrolled study suggest that a high percentage of migraineurs experience excessive daytime sleepiness (EDS). We investigated EDS in a case-control study on 100 patients with episodic migraine and 100 age- and sex-matched healthy controls and also assessed sleep quality, anxiety and depression. Although it was found that EDS was more frequent in migraineurs than in controls (14% vs. 5%; odds ratio 3.1; 95% confidence interval 1.1-8.9), the frequency was lower than previously reported. EDS correlated with migraine disability, sleep problems and anxiety. EDS in patients with migraine probably stems from the full constellation of headache-sleep-affective symptoms resulting from the complex clinical burden of the disease.

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