• Piero Barbanti, Cinzia Aurilia, Gabriella Egeo, Luisa Fofi, and Nicola Vanacore.
• Headache and Pain Unit, IRCCS San Raffaele Pisana, Via della Pisana 235, 00163 Rome, Italy. piero.barbanti@sanraffaele.it
• Sleep Med. 2013 Mar 1; 14 (3): 278-81.

BackgroundExcessive daytime sleepiness is a major clinical and health concern that can have varied and sometimes harmful consequences. Findings from uncontrolled studies suggest a high prevalence in patients with chronic migraine.MethodsIn a case-control study, we compared frequency data for excessive daytime sleepiness in 100 patients with chronic migraine and 100 healthy controls paired for sex and age, and assessed risk factors including lifestyle, sleep quality, anxiety, depression, concomitant disease and medications.ResultsThe frequency of excessive daytime sleepiness was higher in migraineurs (especially in those with medication overuse) than in controls (20% versus 6%; odds ratio 3.92, 95% CI 1.5-10.22), but was lower than previously reported and correlated with poor quality sleep and anxiolytic and antidepressant use.ConclusionsAgain confirming that disability in chronic migraine is multifactorial in origin, excessive daytime sleepiness, especially in migraineurs who overuse medications, adds to the multiple factors known to impair social and working function. Patients with chronic migraine might benefit from diagnostic interviews focussing also on sleep problems and from targeted psychoactive drug prescribing.Copyright © 2012 Elsevier B.V. All rights reserved.

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