• Trends in immunology · Nov 2013

    Innate immune cells in asthma.

    • Julie Deckers.
    • Laboratory of Immunoregulation and Mucosal Immunology, DMBR-VIB, Zwijnaarde, Belgium; Laboratory of Immunoregulation, Ghent University, Ghent, Belgium; Cytokine Receptor Laboratory, VIB Department of Medical Protein Research, Ghent, Belgium.
    • Trends Immunol. 2013 Nov 1; 34 (11): 540-7.

    AbstractAsthma is an inflammatory disease of the airways associated with a T helper (Th)2 response. Such a response in the lungs requires complex interactions between innate cells and structural cells. Dendritic cells (DCs) are pivotal during sensitization to allergens but clearly require epithelium-derived signals to become activated. Epithelial cells also contribute to the activation and the survival of mast cells (MCs), basophils, and eosinophils and group 2 innate lymphoid cells (ILC2s). In turn, these innate cells can activate DCs to sustain Th2 immunity. Here, we review the role played by these different populations of immune cells in the pathogenesis of asthma and how they interact to orchestrate Th2 immunity.Copyright © 2013 Elsevier Ltd. All rights reserved.

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