• J Med Toxicol · Sep 2008

    Four-year experience with methotrexate exposures.

    • Frank LoVecchio, Kenneth Katz, David Watts, and Ian Wood.
    • Banner Good Samaritan Regional Poison Center, Maricopa Medical Center, Department of Emergency Medicine, Phoenix, AZ, USA. Frank.LoVecchio@bannerhealth.com
    • J Med Toxicol. 2008 Sep 1; 4 (3): 149-50.

    IntroductionUnintentional methotrexate (MTX) acute oral overdose is rarely reported.MethodsWe conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003.ResultsThirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred.DiscussionAlthough intravenous MTX toxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.

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