• Catherine Buettner and Rami Burstein.
• Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, USA Harvard Medical School, USA cbuettne@bidmc.harvard.edu.
• Cephalalgia. 2015 Aug 1; 35 (9): 757-66.

ObjectiveThe objective of this article is to evaluate whether statin use and vitamin D status is associated with severe headache or migraine in a nationally representative sample.MethodsWe conducted a cross-sectional study of US individuals aged ≥40 years for whom information on statin use, serum 25-hydroxy vitamin D (25(OH)D), and self-reported severe headache or migraine had been collected. We calculated prevalence estimates of headache according to statin and 25(OH)D, and conducted adjusted logistic regression analyses stratified by the median 25(OH)D (≤57 and >57 nmol/l).ResultsAmong 5938 participants, multivariable-adjusted logistic regression showed that statin use was significantly associated with a lower prevalence of severe headache or migraine (OR 0.67; 95% CI 0.46, 0.98, p = 0.04). We found a significant interaction between statin use and 25(OH)D with the prevalence of severe headache or migraine (p for interaction = 0.005). Among participants who had serum 25(OH)D > 57 nmol/l, statin use was associated with a multivariable-adjusted odds ratio of 0.48 (95% CI 0.32, 0.71, p = 0.001) for having severe headache or migraine. Among those with 25(OH)D ≤ 57 nmol/l, no significant association was observed between statin use and severe headache or migraine.ConclusionStatin use in those with higher serum vitamin D levels is significantly associated with lower odds of having severe headache or migraine.© International Headache Society 2014.

20 keywords...

hide…