• Cancer letters · Sep 2011

    TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells.

    • Gengyun Wen, Michael A Partridge, Bingyan Li, Mei Hong, Wupeng Liao, Simon K Cheng, Yongliang Zhao, Gloria M Calaf, Tian Liu, Jun Zhou, Zengli Zhang, and Tom K Hei.
    • Center for Radiological Research, College of Physicians & Surgeons, Columbia University, New York, NY, USA. gw2154@columbia.edu
    • Cancer Lett. 2011 Sep 1; 308 (1): 23-32.

    AbstractControversy has arisen as to the role of transforming growth factor-β-induced protein (TGFBI) in the regulation of tumor metastasis. Using lung and breast cancer cell lines (H522 and MCF-7, respectively), we established that TGFBI induced cell adhesion to extracellular matrix proteins by activating adhesion-associated signaling and subsequent structure reformation, ultimately leading to cells less motile; whereas TGFBI reduced abilities of colony formation in soft agar, penetration through matrix gel, and activation of matrix metalloproteinases 2 and 9. Furthermore, injection of TGFBI-expressing cells into immuno-deficient mice resulted in a significant reduction in tumor metastasis in vivo. Taken together, these data suggest that TGFBI moderates the metastatic potential of cancer cells.Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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