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- John Eikelboom and Geno Merli.
- Department of Medicine, Division of Hematology and Thromboembolism, McMaster University, Hamilton, Ont, Canada. Electronic address: eikelbj@mcmaster.ca.
- Am. J. Med. 2016 Nov 1; 129 (11S): S33-S40.
AbstractThe risk of bleeding in the setting of anticoagulant therapy continues to be re-evaluated following the introduction of a new generation of direct oral anticoagulants (DOACs). Interruption of DOAC therapy and supportive care may be sufficient for the management of patients who present with mild or moderate bleeding, but in those with life-threatening bleeding, a specific reversal agent is desirable. We review the phase 3 clinical studies of dabigatran, rivaroxaban, apixaban, and edoxaban in patients with nonvalvular atrial fibrillation, in the context of bleeding risk and management.Copyright © 2016 Elsevier Inc. All rights reserved.
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