• J Stroke Cerebrovasc Dis · Jul 2015

    Surgical Revascularization in North American Adults with Moyamoya Phenomenon: Long-Term Angiographic Follow-up.

    • Eric J Arias, Gavin P Dunn, Chad W Washington, Colin P Derdeyn, Michael R Chicoine, Robert L Grubb, Christopher J Moran, DeWitte T Cross, Ralph G Dacey, and Gregory J Zipfel.
    • Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri. Electronic address: ejarias@wustl.edu.
    • J Stroke Cerebrovasc Dis. 2015 Jul 1; 24 (7): 1597-608.

    BackgroundNorth American and Asian forms of moyamoya have distinct clinical characteristics. Asian adults with moyamoya are known to respond better to direct versus indirect revascularization. It is unclear whether North American adults with moyamoya have a similar long-term angiographic response to direct versus indirect bypass.MethodsA retrospective review of surgical revascularization for adult moyamoya phenomenon was performed. Preoperative and postoperative cerebral angiograms underwent consensus review, with degree of revascularization quantified as extent of new middle cerebral artery (MCA) territory filling.ResultsLate angiographic follow-up was available in 15 symptomatic patients who underwent 20 surgical revascularization procedures. In 10 hemispheres treated solely with indirect arterial bypass, 3 had 2/3 revascularization, 4 had 1/3 revascularization, and 3 had no revascularization of the MCA territory. In the 10 hemispheres treated with direct arterial bypass (8 as a stand-alone procedure and 2 in combination with an indirect procedure), 2 had complete revascularization, 7 had 2/3 revascularization, and 1 had 1/3 revascularization. Direct bypass provided a higher rate of "good" angiographic outcome (complete or 2/3 revascularization) when compared with indirect techniques (P = .0198).ConclusionsDirect bypass provides a statistically significant, more consistent, and complete cerebral revascularization than indirect techniques in this patient population. This is similar to that reported in the Asian literature, which suggests that the manner of presentation (ischemia in North American adults versus hemorrhage in Asian adults) is likely not a contributor to the extent of revascularization achieved after surgical intervention.Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

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