• Neurology · Jul 2017

    Modulation of intrinsic resting-state fMRI networks in women with chronic migraine.

    • X Michelle Androulakis, Kaitlin Krebs, B Lee Peterlin, Tianming Zhang, Nasim Maleki, Souvik Sen, Chris Rorden, and Priyantha Herath.
    • From the Departments of Neurology (X.M.A., K.K., S.S., P.H.), Statistics (T.Z.), and Psychology (C.R.), University of South Carolina, Columbia; Department of Neurology (B.L.P.), Johns Hopkins University, Baltimore, MD; and Department of Psychiatry (N.M.), Massachusetts General Hospital, Boston. Michelle.Androulakis@uscmed.sc.edu.
    • Neurology. 2017 Jul 11; 89 (2): 163-169.

    ObjectiveTo evaluate the intrinsic resting functional connectivity of the default mode network (DMN), salience network (SN), and central executive network (CEN) network in women with chronic migraine (CM), and whether clinical features are associated with such abnormalities.MethodsWe analyzed resting-state connectivity in 29 women with CM as compared to age- and sex-matched controls. Relationships between clinical characteristics and changes in targeted networks connectivity were evaluated using a multivariate linear regression model.ResultsAll 3 major intrinsic brain networks were less coherent in CM (DMN: p = 0.030, SN: p = 0.007, CEN: p = 0.002) as compared to controls. When stratified based on medication overuse headache (MOH) status, CM without MOH (DMN: p = 0.029, SN: p = 0.023, CEN: p = 0.003) and CM with MOH (DMN: p = 0.016, SN: p = 0.016, CEN: p = 0.015) were also less coherent as compared to controls. There was no difference in CM with MOH as compared to CM without MOH (DMN: p = 0.382, SN: p = 0.408, CEN: p = 0.419). The frequency of moderate and severe headache days was associated with decreased connectivity in SN (p = 0.003) and CEN (p = 0.015), while cutaneous allodynia was associated with increased connectivity in SN (p = 0.011).ConclusionsOur results demonstrated decreased overall resting-state functional connectivity of the 3 major intrinsic brain networks in women with CM, and these patterns were associated with frequency of moderate to severe headache and cutaneous allodynia.© 2017 American Academy of Neurology.

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