• Dis. Colon Rectum · Jan 1998

    Case Reports

    Treatment of therapy-resistant perineal metastatic Crohn's disease after proctectomy using anti-tumor necrosis factor chimeric monoclonal antibody, cA2: report of two cases.

    • H M van Dullemen, E de Jong, F Slors, G N Tytgat, and S J van Deventer.
    • Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands.
    • Dis. Colon Rectum. 1998 Jan 1; 41 (1): 98-102.

    PurposeTwo young females with well-documented Crohn's disease and nonhealing perineal wounds following proctectomy compatible with "metastatic Crohn's disease" are described. We hypothesized that metastatic Crohn's disease would be a tumor necrosis factor-dependent inflammatory reaction and have treated these two patients with the anti-tumor necrosis factor chimeric monoclonal antibody, cA2.Main FindingsAdministration of cA2 was followed by a rapid reduction of subjective and objective parameters of inflammation and caused a substantial reduction of the wound size.ConclusionThese preliminary data are consistent with a tumor necrosis factor-dependent inflammatory cause of Crohn's disease and its extraintestinal manifestations and provide support for targeting tumor necrosis factor in this condition.

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