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J Pain Palliat Care Pharmacother · Mar 2015
The attractiveness of opposites: agonists and antagonists.
- Tony O'Brien.
- Tony O'Brien, MB, FRCPI, is Professor and Consultant in Palliative Medicine at Marymount University Hospital & Hospice/Cork University Hospital, Ireland and at the College of Medicine and Health, University College , Cork , Ireland.
- J Pain Palliat Care Pharmacother. 2015 Mar 1; 29 (1): 67-9.
AbstractOpioid-induced bowel dysfunction, of which constipation is the most common aspect, is a major limiting factor in the use of opioids for pain management. The availability of an oral, long-acting formulation of oxycodone and naloxone represents a highly significant development in pain management. The combination of an opioid analgesic with an opioid antagonist offers reliable pain control with a significant reduction in the burden of opioid-induced constipation.
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