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J Pain Palliat Care Pharmacother · Jan 2015
Case ReportsFentanyl-Induced Neurotoxicity in Children.
- Shrenik Ostwal, Naveen Salins, Jayita Deodhar, and Mary Ann Muckaden.
- J Pain Palliat Care Pharmacother. 2015 Jan 1; 29 (4): 385-7.
AbstractFentanyl-induced neurotoxicity is an uncommon adverse effect of fentanyl and is seldom seen in pediatric palliative care practice. It presents as myriad of nonspecific symptoms such as severe pain, allodynia, insomnia, agitation, hallucinations, behavioral changes, and headache. In children, it is often missed and misdiagnosed. This is a case report of an 11-year-old girl; a case of locally advanced neuroblastoma, progressed on disease-modifying treatment, and referred to pediatric palliative care for best supportive care. She developed features of fentanyl-induced neurotoxicity during upward titration of transdermal fentanyl that was promptly identified and managed in a pediatric palliative care setting.
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