• Cristiana Guetti, Chiara Angeletti, Alessandra Ciccozzi, Antonella Paladini, Alba Piroli, and Paolo Matteo Angeletti.
• Anesthesiology and Pain Medicine, Department of Health Sciences, University of L'Aquila, Italy.
• Pain Pract. 2013 Nov 1;13(8):657-62.

AbstractThe fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases. Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.© 2013 The Authors Pain Practice © 2012 World Institute of Pain.

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