• Anaesth Intensive Care · Mar 2018

    Case Reports

    Postoperative euglycaemic diabetic ketoacidosis associated with sodium-glucose cotransporter-2 inhibitors (gliflozins): a report of two cases and review of the literature.

    • B Chacko, M Whitley, U Beckmann, K Murray, and M Rowley.
    • Nephrologist, Newcastle Private Hospital; Senior Staff Specialist, Nephrology and Transplantation Unit, John Hunter Hospital; Conjoint Senior Lecturer, School of Medicine and Public Health, University of Newcastle; Newcastle, New South Wales.
    • Anaesth Intensive Care. 2018 Mar 1; 46 (2): 215-219.

    AbstractSodium-glucose cotransporter 2 inhibitor (SGLT2i)-associated euglycaemic diabetic ketoacidosis (euDKA) is a serious and increasingly recognised complication of treatment with this class of oral hypoglycaemic agents and can present a diagnostic challenge, resulting in delayed recognition, inappropriate treatment and potentially life-threatening acidosis. We present two cases of patients developing SGLT2i-associated euDKA in the early postoperative period. We support ceasing SGLT2i for 72 hours preoperatively and would suggest continuing to withhold the medication until oral intake is restored, and recommend a wider awareness of SGLT2i-associated diabetic ketoacidosis (DKA) amongst patients and their healthcare providers with an emphasis on checking ketone levels irrespective of blood glucose levels in the postoperative setting.

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