• Lutz Goldbeck, Friedrich Gagsteiger, Inge Mindermann, Stefanie Ströbele, and Yonca Izat.
• Department of Child and Adolescent Psychiatry/Psychotherapy, University Ulm, Ulm, Germany. lutz.goldbeck@uniklinik-ulm.de
• J Pediatr Psychol. 2009 Aug 1; 34 (7): 774-81.

ObjectiveTo investigate the cognitive functioning of low-risk singletons born after intracytoplasmic sperm injection (ICSI) or in vitro fertilization (IVF) at the age of 5 or 10 years.MethodsSixty-nine children (35 ICSI, 34 IVF) participated voluntarily in the study that had been approved by the local IRB. Their intellectual functioning was examined by the Kaufmann Assessment Battery for Children.ResultsThe IQ of the study group fell in the normal range (mean = 98.2; SD = 12.2). ICSI children (IQ = 94.1, SD = 13.8) had statistically lower intellectual abilities compared to IVF children (IQ = 102.0, SD = 9.1; t = -2.81, p = .005), especially in simultaneous mental processing. 23.5% ICSI children, but only 2.9% IVF children (p = .011) had at least borderline delayed cognitive development.ConclusionsMost artificially conceived singletons show a normal cognitive development, however the method of fertilization seems to have an impact on their IQ. ICSI might be associated with the risk for a slightly delayed cognitive development compared to IVF.

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