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Anesthesia and analgesia · Oct 2019
Comparative Study Observational StudyThe Effect of Repeated Versus Initial Procalcitonin Measurements on Diagnosis of Infection in the Intensive Care Setting: A Prospective Observational Study.
- Phillip D Levin, Matan J Cohen, Eden Ohev-Zion, Samer Tannus, Sheldon Stohl, Alexander Avidan, Ronit Cohen-Poraduso, Allon E Moses, Charles L Sprung, and Shmuel Benenson.
- From the Department of Anesthesiology.
- Anesth. Analg. 2019 Oct 1; 129 (4): e114-e117.
AbstractProcalcitonin (PCT) measurement has been proposed to direct antibiotic use. We examined whether repeated PCT measurements (0, 6, and/or 12 hours) versus the initial measurement only (time 0) increased the sensitivity and specificity of PCT for diagnosing infection in intensive care unit patients. Infection was identified in 67/176 (38%) patients. The sensitivity of repeated versus the initial PCT measurement (with a cutoff value 0.5 ng/mL) was 52/67 (77%; 95% confidence interval [CI], 66%-87%) vs 46/67 (69%; 95% CI, 56%-79%; P = .04) and specificity 60/109 (55%; 95% CI, 45%-65%) vs 59/109 (54%; 95% CI, 44%-64%; P = 1.0). Repeat PCT evaluations over 12 hours did not provide a clinically significant improvement in diagnostic accuracy when compared to the initial single test.
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