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- Jairo Alberto Dussán-Sarria, Nadia Regina Jardim da Silva, Alicia Deitos, StefaniLuciana CadoreLCPostgraduation Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.Laboratory of Pain and Neuromodulation, Hospital de Clínicas de Porto Alegre (HCPA)/UFRGS, P, Gabriela Laste, SouzaAndressa deALaboratory of Pain and Neuromodulation, Hospital de Clínicas de Porto Alegre (HCPA)/UFRGS, Porto Alegre, RS, Brazil.La Salle University, Canoas, RS, Brazil., TorresIraci L SILSPostgraduation Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.Pharmacology Department, Instituto de Ciências Básicas da Saúde, UFRGS, Porto Alegre, RS, Brazil., Felipe Fregni, and Wolnei Caumo.
- Postgraduation Program in Medical Sciences, School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
- Pain Med. 2018 Aug 1; 19 (8): 1578-1586.
BackgroundAlthough the brain-derived neurotrophic factor (BDNF) has been intensively investigated in animal models of chronic pain, its role in human pain processing is less understood.ObjectiveTo study the neurophysiology of BDNF modulation on acute experimental pain, we performed a cross-sectional study.MethodsWe recruited 20 healthy male volunteers (19-40 years old) and assessed their serum BDNF levels, quantitative sensory testing, and cortical excitability parameters using transcranial magnetic stimulation.ResultsLinear regression models demonstrated that the BDNF (β = -5.245, P = 0.034) and intracortical facilitation (β = -3.311, P = 0.034) were inversely correlated with heat pain threshold (adjusted R2 = 44.26). The BDNF (β = -3.719, P ≤ 0.001) was also inversely correlated with conditioned pain modulation (adjusted R2 = 56.8).ConclusionsOur findings indicate that higher serum BDNF and intracortical facilitation of the primary motor cortex are associated with increased sensitivity to heat pain and high serum BDNF with reduced pain inhibition during noxious heterotopic stimulation.
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