• Ned Tijdschr Geneeskd · Jan 2012

    [Endoscopic versus surgical treatment of infected necrotising pancreatitis: the TENSION study].

    • Sandra van Brunschot, Hjalmar C van Santvoort, Hein G Gooszen, and Paul Fockens.
    • Universitair Medisch Centrum St Radboud, afd. OK/evidence based surgery, Nijmegen, the Netherlands. s.vanbrunschot@ok.umcn.nl
    • Ned Tijdschr Geneeskd. 2012 Jan 1; 156 (4): A4329.

    AbstractIn patients with infected necrotising pancreatitis there is a significant risk (40%) of complications and mortality with the surgical step-up approach. This approach consists of percutaneous retroperitoneal drainage, if necessary followed by video-assisted retroperitoneal débridement. An alternative treatment is an endoscopic step-up approach consisting of endoscopic transluminal drainage, if necessary followed by endoscopic transluminal necrosectomy. The Dutch Pancreatitis Study Group has recently started the nationwide randomized TENSION-trial, in which in 98 patients the endoscopic step-up approach is compared with the surgical method. The primary endpoint is a composite of mortality and major morbidity (new onset organ failure, bleeding, perforation of a hollow organ or incisional hernia for which intervention is needed).

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