• J Clin Pharm Ther · Apr 2013

    Polymorphisms of the HTR3B gene are associated with post-surgery emesis in a Chinese Han population.

    • Xiao-Xu Ma, Qi-Xing Chen, Shui-Jing Wu, Yan Hu, and Xiang-Ming Fang.
    • Department of Anesthesiology, Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine, Hangzhou, China.
    • J Clin Pharm Ther. 2013 Apr 1; 38 (2): 150-5.

    What Is Known And ObjectivesThe serotoninergic receptor 5-hydroxytryptamine (serotonin) receptor 3 (HTR3) is instrumental in the regulation of nausea and emesis (vomiting).This study investigated whether common genomic variations of the A and B subunits of HTR3 (HTR3A, HTR3B) are associated with the incidence of post-operative vomiting in a Chinese Han population.MethodsTwo hundred and thirty-one female Chinese Han patients undergoing gynaecological surgery with standardized general anaesthesia were recruited for the study. Clinical symptoms after surgery were recorded and direct DNA sequencing was performed to detect polymorphisms of HTR3A and HTR3B.ResultsFive single nucleotide polymorphisms (SNPs) in HTR3A and HTR3B were found, with R(2)  > 0·8 and minor allele frequency > 10%. One of these (rs3758987 in HTR3B) was statistically associated with vomiting, after adjusting for body weight, body mass index and duration of general anaesthesia in dominant and additive models (P = 0·047 and P = 0·034).What Is New And ConclusionThe HTR3B rs3758987 SNP might serve as a predictor of post-operative vomiting in Chinese Han patients undergoing gynaecological laparoscopic surgery.© 2013 Blackwell Publishing Ltd.

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