• Pharmacol Rep · Jan 2011

    Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK.

    • Mayur I Patel, Amit Gupta, and Chinmoy S Dey.
    • Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sec 67, S.A.S. Nagar, Punjab 160 062, India.
    • Pharmacol Rep. 2011 Jan 1; 63 (5): 1162-8.

    AbstractResveratrol (RSV), a polyphenolic phytoestrogen, has been shown to activate the serine/threonine kinase 5'-adenosine monophosphate-activated protein kinase (AMPK) and to stimulate insulin signaling and glucose uptake in skeletal muscle cells. A direct effect of RSV on neuronal insulin signaling, however, has not been demonstrated. Here, we report that RSV stimulates glucose uptake and potentiates insulin signaling in Neuro-2A (N2A) cells, which is characterized by the increased phosphorylation of protein kinase B (Akt) and glycogen synthase kinase-3β (GSK-3β). Furthermore, RSV activates AMPK in N2A cells, which can be prevented using a specific pharmacological inhibitor, Compound C. Compound C abrogates RSV-induced Akt and GSK-3β phosphorylation and glucose uptake. Thus, we demonstrate that RSV potentiates insulin signaling and glucose uptake via AMPK activation in neuronal cells.

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