• L Rowe, J G Jones, D Quine, S S Bhushan, and B J Stenson.
• Department of Anaesthetics, Norfolk and Norwich University Hospital, Norwich, UK.
• Arch. Dis. Child. Fetal Neonatal Ed. 2010 Jan 1; 95 (1): F47-52.

BackgroundRight to left shunt and regional hypoventilation (reduced ventilation/perfusion ratio (V(A)/Q)) have different effects on the curve relating inspired oxygen (P(I)O(2)) to oxygen saturation measured by pulse oximetry (SpO(2)) and can be derived non-invasively from measurements of SpO(2) and inspired oxygen pressure (P(I)O(2)) using complex models of gas exchange. We developed a simpler computerised "slide-rule" method of making these derivations.AimsTo describe the slide-rule method and determine agreement between measurements derived with this and a more complex algorithm.MethodsSeries of P(I)O(2) versus SpO(2) data points obtained during 43 studies in 16 preterm infants with bronchopulmonary dysplasia were analysed. Percentage shunt and the degree of right shift (kPa) of the P(I)O(2) versus SpO(2) curve compared with the oxyhaemoglobin dissociation curve (a measure of V(A)/Q) were determined for each dataset with both methods, and the results were compared using the method of Bland and Altman.ResultsThe computer slide-rule method produced results for all 43 datasets. The more complex model could derive results for 40/43 datasets. The mean differences (95% limits of agreement) between the two methods for measurements of shunt were -1.7% (-6.5 to +3.5%) and for measurements of right shift were 0.3 kPa (-2.9 to +3.6 kPa).ConclusionThe slide-rule method was reliable for deriving shunt and right shift (reduced V(A)/Q) of the P(I)O(2) versus SpO(2) curve when compared with the more complex algorithm. The new method should enable wider clinical application of these measurements of oxygen exchange.

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