• Adv Exp Med Biol · Jan 2016

    Hypoxia and Neonatal Haemorrhagic Stroke: Experimental Study of Mechanisms.

    • Oxana Semyachkina-Glushkovskaya, Ekaterina Borisova, Anton Namikin, Ivan Fedosov, Arkady Abdurashitov, Ekaterina Zhinchenko, Artem Gekalyuk, Maria Ulanova, Victoria Rezunbaeva, Latchezar Avramov, Dan Zhu, Qingming Luo, and Valery Tuchin.
    • Saratov State University, Astrakhanskaya Str. 83, Saratov, 410012, Russia. glushkovskaya@mail.ru.
    • Adv Exp Med Biol. 2016 Jan 1; 923: 173-179.

    AbstractWe studied the level of blood oxygen saturation (SpO2) in the brain in newborn rats in the pre- and post-stroke periods, as well as the changes in cerebral blood flow and beta-arrestin-1 as a marker of hypoxic stress. Our results show that mild hypoxia precedes the stroke development and is associated with venous relaxation and decrease blood outflow from the brain resulting in the elevation of synthesis of beta-arrestin-1 in the brain. The incidence of stroke is characterized by severe hypoxia, which is accompanied by the progression of pathological changes in cerebral veins and the high level of beta-arrestin-1.

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