• Sotiris C Plastiras, Fotini C Soliotis, Panayiotis Vlachoyiannopoulos, and George E Tzelepis.
• Department of Pathophysiology, University of Athens Medical School, Athens, Greece. splastiras@panafonet.gr
• Clin. Rheumatol. 2007 Jan 1; 26 (1): 108-11.

AbstractInterstitial lung disease in patients with antisynthetase syndrome and no evidence of myositis is rare and may precede other disease manifestations. We report a patient who initially presented with symptoms primarily related to lung involvement. The diagnosis of the antisynthetase syndrome without myositis was made many months later when he developed a characteristic hand rash (mechanic's hands), which was confirmed by positive antibodies to Jo-1. With treatment, both the hand rash and the interstitial lung disease improved. Antisynthetase syndrome should be considered in patients presenting with interstitial lung disease with no evidence of myositis. Appropriate laboratory testing with measurement of specific autoantibodies may help in the early diagnosis and treatment of the syndrome.

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