• Leonardo B C Brasiliense, Nicholas Theodore, Bruno C R Lazaro, Zafar A Sayed, Fatih Ersay Deniz, Volker K H Sonntag, and Neil R Crawford.
• Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
• J Neurosurg Spine. 2010 May 1; 12 (5): 503-8.

ObjectThe object of this study was to investigate the effects of iatrogenic pedicle perforations from screw misplacement on the mean pullout strength of thoracic pedicle screws.MethodsForty human thoracic vertebrae (T6-11) from human cadavers were studied. Before pedicle screws were inserted, the specimens were separated into 4 groups according to the type of screw used: 1) standard pedicle screw (no cortical perforation); 2) screw with medial cortical perforation; 3) screw with lateral cortical perforation; and 4) "airball" screw (a screw that completely missed the vertebral body). Consistency among the groups for bone mineral density, pedicle diameter, and screw insertion depth was evaluated. Finally, each screw was pulled out at a constant displacement rate of 10 mm/minute while ultimate strength was recorded.ResultsCompared with well-placed pedicle screws, medially misplaced screws had 8% greater mean pullout strength (p = 0.482) and laterally misplaced screws had 21% less mean pullout strength (p = 0.059). The difference in mean pullout strength between screws with medial and lateral cortical perforations was significant (p = 0.013). Airball screws had only 66% of the mean pullout strength of well-placed screws (p = 0.009) and had 16% lower mean pullout strength than laterally misplaced screws (p = 0.395).ConclusionsThis in vitro study showed a significant difference in mean pullout strength between medial and lateral misplaced pedicle screws. Moreover, airball screws were associated with a significant loss of pullout strength.

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