• Br J Obstet Gynaecol · Jul 1998

    Expression of endothelin-1 in amniotic fluid embolism and possible pathophysiological mechanism.

    • T Y Khong.
    • Department of Histopathology, Adelaide Women's and Children's Hospital, Australia.
    • Br J Obstet Gynaecol. 1998 Jul 1; 105 (7): 802-4.

    AbstractSince endothelin is a potent vasoconstrictor and bronchoconstrictor, endothelin-1 expression in the lung was investigated using immunohistological techniques in two cases of amniotic fluid embolism. Intense expression of endothelin-1 was observed in amniotic squames while weaker staining was seen in alveolar epithelium, bronchiolar epithelium and intraalveolar macrophages and focally in vascular endothelium. Endothelin-1 may play a role in the early and transient haemodynamic alteration of pulmonary hypertension in amniotic fluid embolism.

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