• Phytomedicine · Aug 2013

    Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain.

    • Haiyan Wang, Yuxiang Li, Linglu Dun, Yaqiong Xu, Shaojv Jin, Juan Du, Lin Ma, Juan Li, Ru Zhou, Xiaoliang He, Tao Sun, and Jianqiang Yu.
    • Department of Pharmacology, Ningxia Medical University, Yinchuan, China.
    • Phytomedicine. 2013 Aug 15; 20 (11): 1039-45.

    PurposeIn this study we investigated antinociceptive effects of oxymatrine through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a chronic neuropathic pain model induced by chronic constrictive injury (CCI) of the sciatic nerve.MethodsThe von Frey and plantar tests were performed to assess the degree of mechanical and thermal changes respectively. Immunohistochemistry assay was used to evaluate the expressions of NR2B. Western blotting assay were used to evaluate the expressions of NR2B, tERK, p-ERK, tCREB and p-CREB.ResultsThe intraperitoneal administration of OMT (160, 80 mg/kg) could prevent the development of mechanical allodynia, thermal hyperalgesia induced by CCI. Intraperitoneal administration of OMT decreased the mean IOD of NR2B in the dorsal horn and expression of NR2B, p-ERK and p-CREB protein.ConclusionRegulation of NMDA NR2B receptor-ERK/CREB signaling maybe the targets for the antinociceptive effects of OMT on a chronic neuropathic pain model induced by chronic constrictive injury of the sciatic nerve.Copyright © 2013 Elsevier GmbH. All rights reserved.

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