• J Arthroplasty · May 2016

    Randomized Controlled Trial Multicenter Study Comparative Study

    Topical vs Intravenous Tranexamic Acid in Primary Total Hip Arthroplasty: A Double-Blind, Randomized Controlled Trial.

    • Wayne T North, Nima Mehran, Jason J Davis, Craig D Silverton, Robb M Weir, and Michael W Laker.
    • Division of adult reconstructive surgery, Henry Ford Hospital, Detroit, Michigan.
    • J Arthroplasty. 2016 May 1; 31 (5): 1022-6.

    BackgroundTranexamic acid (TXA) reduces perioperative blood loss in total hip arthroplasty (THA).MethodsIn our randomized control trial, 139 patients were enrolled and received 2 g of either topical or intravenous (IV) TXA. Preoperative and postoperative protocols were standardized.ResultsCalculated blood and Hgb loss were lower in the IV group (1195.0 ± 485.9 mL, 1442.7 ± 562.7 mL; P = .006), (160.3 [g] ± 63.8, 188.4 [g] ± 68.5; P = .014). There was a trend toward significance in transfusion reduction (11% [IV] vs 18% [topical]; P = .3). Both groups effectively reduced the transfusion rate. There was significant financial incentive for the use of TXA in THA with a savings of $314 per patient.ConclusionsIV and topical TXA are effective tools to reduce blood loss and transfusion costs in THA, and we recommend the IV form for ease of use.Copyright © 2016 Elsevier Inc. All rights reserved.

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