• D Noguera-Gonzalez, B I Cerda-Cristerna, D Chavarria-Bolaños, H Flores-Reyes, and A Pozos-Guillen.
• Endodontic Postgraduate Program and Basic Sciences Laboratory, Faculty of Dentistry, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México.
• Int Endod J. 2013 Nov 1; 46 (11): 1056-62.

AimTo evaluate the effect of preoperative oral ibuprofen (IBU) on the success of inferior alveolar nerve blocks (IANBs) with mepivacaine containing 1 : 100 000 epinephrine for patients with symptomatic irreversible pulpitis (SIP).MethodologyThe present study was a double-blind, randomized, placebo-controlled clinical trial. The study included two study groups each consisting of 25 patients who exhibited symptomatic irreversible pulpitis of a mandibular posterior tooth. The patients presented prolonged moderate or severe pain (>10 s) after cold testing and indicated their pain scores on a Heft-Parker visual analogue scale. The patients received identically appearing capsules containing either 600 mg IBU (IBUg) or gelatin (placebo, PLAg) 1 h before administration of IANB with 2% mepivacaine containing 1 : 100 000 epinephrine. After 15 min, the anaesthetic blockade was assessed by a three-step examination (lip numbness, positive/negative response to cold testing and clinical discomfort during endodontic access). IANB success was defined as the absence of pain during any of these evaluations. The data were analysed using the chi-squared test.ResultsAll of the patients reported moderate or severe pain before the preoperative procedure. Statistically significant differences were observed between the IBUg and PLAg (P < 0.05); the success rates for the IANB were 72% (IBUg) and 36% (PLAg).ConclusionsPreoperative oral administration of IBU significantly improved the efficacy of IANB in patients with symptomatic irreversible pulpitis.© 2013 International Endodontic Journal. Published by John Wiley & Sons Ltd.

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