• Seiichiro Imataka, Yukinori Akiyama, Rintaro Yokoyama, and Nobuhiro Mikuni.
• Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
• World Neurosurg. 2018 Mar 1; 111: 240-242.

BackgroundGlioblastoma, also known as glioblastoma multiforme, is the most common primary malignant cerebral tumor in adults. Although glioblastoma multiforme is one of the most aggressive tumors in the brain, propagation through the dura mater is rare.Case DescriptionA 59-year-old man presented with progressive headache and aphasia. Magnetic resonance imaging identified an abnormal mass extending transcranially through the widened foramen rotundum into the infratemporal fossa and cavernous sinus. Emergency surgery was performed because of the patient's disturbed consciousness and uncal herniation. The pathologic diagnosis was glioblastoma with isocitrate dehydrogenase 1 (IDH-1) wild type arising in the left temporal region of the brain, penetrating the dura mater and propagating to the middle fossa with enlargement of the foramen rotundum. The tumor was resected, and radiochemotherapy with temozolomide was administered.ConclusionAlthough the mechanism of tumor spread is unknown, we hypothesized that originally there may have been spontaneous dural defects or thinning, such as a meningoencephalocele in the middle fossa, and the tumor coincidentally occurred there.Copyright © 2017. Published by Elsevier Inc.

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