• D Scott Lawson, Richard Ing, Ira M Cheifetz, Rich Walczak, Damian Craig, Scott Schulman, Frank Kern, Ian R Shearer, Andrew Lodge, and James Jaggers.
• Department of Perfusion Services, Duke University Health System, Durham, NC, USA.
• Pediatr Crit Care Me. 2005 Sep 1; 6 (5): 573-7.

ObjectiveAs compared with traditional extracorporeal roller-occlusion blood pumps, nonocclusive centrifugal pumps offer the benefits of requiring a smaller circuit surface area and, thus, a smaller prime volume. However, centrifugal blood pumps have been reported to generate unacceptable levels of hemolysis. We hypothesize that the newer generation centrifugal pumps have an incidence of hemolysis similar to the traditional roller head pumps and, thus, could be used for extracorporeal membrane oxygenation circuits.DesignRandomized, prospective, bench study.SettingUniversity research laboratory.InterventionsThree centrifugal blood pumps (Cobe Revolution, Jostra Rotaflow, and Medtronic BioMedicus) were compared with a roller occlusion blood pump (Cobe Century). Hemolysis generation was examined during 6 hrs of continuous use. Two test runs per group were randomly performed on three consecutive days for a total of six test runs for each of the four pumps (n = 24).Measurements And Main ResultsPlasma free hemoglobin values were determined using a Spectra MaxPlus spectrophotometer. A normalized index of hemolysis was calculated to compare the individual trials. The Cobe Revolution and the Jostra Rotaflow compared favorably with the Cobe Century roller occlusion blood pump in the amount of hemolysis produced.ConclusionsThese data are encouraging for the development of a low-prime, mobile neonatal extracorporeal membrane oxygenation circuit using centrifugal pump technology.

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