• Tianwei Wang, Xiaodong Niu, Ting Gao, Lingling Zhao, Jiaoming Li, Youjun Gan, Yanhui Liu, and Qing Mao.
• Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
• World Neurosurg. 2018 Apr 1; 112: e269-e277.

ObjectiveThe purpose of this study was to perform a survival analysis of patients with high-grade multicentric gliomas and to assess the influence of various prognostic factors on overall survival (OS).MethodsA literature search on PubMed and Web of Science was performed for literature in English published from 1880 to October 2017. Detailed information including demographics, clinical characteristics, treatments, critical events, and time to events for survival analysis were extracted from the included articles.ResultsA total of 73 cases from 25 published articles were selected for analysis. Univariate analysis showed the surgery (SB/SR), age (<54/≥54 years), radiotherapy (Y/N), and suprainfratentorial gliomas (Y/N) had significant correlations with OS. Multivariate analysis showed that age, surgery, and radiotherapy were independent prognostic factors. Univariate and multivariate analysis revealed radiotherapy and radiotherapy combined with chemotherapy were independent prognostic factors for surgical patients' OS.ConclusionsThis comprehensive analysis of multicentric glioma patients revealed that age younger than 54 years, surgical resection, and radiotherapy were significantly associated with improved survival and were independent prognostic factors for OS. Radiotherapy and radiotherapy combined with chemotherapy were independent prognostic factors for surgical patients' OS as well.Copyright © 2018 Elsevier Inc. All rights reserved.

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