• Yijun Xue, Xiaofeng Zou, Guoxi Zhang, Yuanhu Yuan, Rihai Xiao, Yunfeng Liao, Xin Zhong, Bo Jiang, Ruiquan Xu, Yuhua Zou, Gang Xu, Kunlin Xie, and Xu Zhang.
• Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, People's Republic of China.
• Eur. Urol. 2015 Aug 1; 68 (2): 302-10.

BackgroundThe feasibility of hybrid transvaginal NOTES (natural orifice transluminal endoscopic surgery) nephrectomy (HTNN) has already been demonstrated. However, pure transvaginal NOTES nephrectomy (PTNN) has been limited to animal experiments with only one report of its use in humans.ObjectiveTo describe our initial experience with HTNN and a stepwise transition towards PTNN.Design, Setting, And ParticipantsBetween May 2010 and September 2011, 63 patients underwent nephrectomy (60 HTNNs and 3 PTNNs) in our institution, including 45 patients with benign renal disease and 18 patients with malignant renal disease.Surgical ProcedureOf the HTNNs, 33 were performed using two umbilical trocars and one transvaginal trocar, and 27 were performed using one umbilical trocar and a transvaginal multi-instrument access port; 3 PTNNs were performed using a self-developed, three-channel ZOU-port without any transumbilical assistance.Outcome Measurements And Statistical AnalysisAll data referring to patient demographics, surgery, pathology, and perioperative outcomes were recorded. Sexual function was assessed with the Female Sexual Function Index (FSFI) questionnaire before and after surgery. The cosmetic result was investigated by administering the Patient Scar Assessment Questionnaire and Scoring System (PSAQ).Results And LimitationsA total of 59 HTNNs and 3 PTNNs were successfully performed. One patient was converted to open surgery because of injury to the inferior vena cava. The mean operative time was 130min (range: 100-260min) for HTNN and 193min (range: 180-210min) for PTNN. The mean estimated blood loss was 150ml. The mean postoperative hospital stay was 7.4 d. Forty-eight patients completed the FSFI questionnaire, and analysis did not show differences in FSFI scores before and after surgery. The better cosmetic results were confirmed by the PSAQ score.ConclusionsHTNN is feasible and safe in appropriate patients. Existing instruments are adequate for HTNN, but significant improvement is still needed. PTNN is technically challenging, but is feasible and may be performed safely. Further improvement of instruments is necessary for PTNN. Clinical investigation in comparison to the established techniques should take place to evaluate the outcome of technique.Patient SummaryPure transvaginal natural orifice transluminal endoscopic nephrectomy (PTNN) is technically challenging but feasible and may be performed safely. Further improvements in instruments are necessary for PTNN.Copyright © 2015 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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