• World Neurosurg · Apr 2018

    Adjustable Polyurethane Foam as Filling Material for a Novel Spondyloplasty: Biomechanics and Biocompatibility.

    • Hongzhen Jiang, Kerim Hakan Sitoci-Ficici, Clemens Reinshagen, Marek Molcanyi, Jozef Zivcak, Radovan Hudak, Thorsten Laube, Matthias Schnabelrauch, Jürgen Weisser, Ute Schäfer, Thomas Pinzer, Gabriele Schackert, Xifeng Zhang, Mario Wähler, Uta Brautferger, and Bernhard Rieger.
    • Department of Neurosurgery, University Hospital of Dresden, Dresden, Germany; University Comprehensive Spine Center, University Hospital of Dresden, Dresden, Germany; Department of Orthopedic Surgery, Second Hospital of Shanxi Medical University, Taiyuan, China; Minimal Invasive Spine Surgery Center, Chinese PLA General Hospital, Beijing, China.
    • World Neurosurg. 2018 Apr 1; 112: e848-e858.

    ObjectiveTo investigate the biomechanics and biocompatibility of polyurethane (PU) foam with adjustable stiffness as a filling material for a novel spondyloplasty that is designed to reduce the risk of postoperative adjacent level fractures.MethodsSixty individual porcine lumbar vertebrae were randomly split into 4 groups: A, B, C, and D. Group A served as unmodified vertebral body controls. Groups B, C, and D consisted of hollowed vertebral bodies. Vertebrae of groups C and D were filled with adjustable PU foams of different stiffness. The compressive strength and stiffness of vertebrae from groups A-D were recorded and analyzed. 3T3 mouse fibroblasts were cultured with preformed PU foams for 4 days to test biocompatibility.ResultsThe strength and stiffness of the hollowed groups were lower than in group A. However, the differences were not statistically significant between group A and group C (P > 0.05), and were obviously different between group A and group B or group D (P < 0.01 and <0.05, respectively). Moreover, the strength and stiffness after filling foams in group C or group D were significantly greater than in group B (P < 0.01 and <0.05, respectively). Live/dead staining of 3T3 cells confirmed the biocompatibility of the PU foam.ConclusionsThe new PU foam shows adaptability regarding its stiffness and excellent cytocompatibility in vitro. The results support the clinical translation of the new PU foams as augmentation material in the development of a novel spondyloplasty.Copyright © 2018 Elsevier Inc. All rights reserved.

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