• Tomasz Jazwiec, Marcin Malinowski, Alastair G Proudfoot, Lenora Eberhart, David Langholz, Hans Schubert, Jeremy Wodarek, and Tomasz A Timek.
• Division of Cardiothoracic Surgery, Spectrum Health, Grand Rapids, Mich; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland.
• J. Thorac. Cardiovasc. Surg. 2018 Oct 1; 156 (4): 1503-1511.

ObjectivesClinical and experimental tricuspid valve physiology data are derived predominantly from anesthetized subjects, but normal tricuspid valve geometry and dynamics may be altered by general anesthesia and mechanical ventilation. We set out to investigate 3-dimensional geometry and dynamics of the tricuspid valve complex in awake and anesthetized sheep.MethodsWhile on cardiopulmonary bypass and with the heart beating, 6 adult sheep (50 ± 8 kg) underwent implantation of 6 sonomicrometry crystals around the tricuspid annulus. One crystal was implanted on the anterior, posterior, and septal papillary muscle tips, 4 on the right ventricular free wall and 1 on its apex. Pressure transducers were placed in both ventricles. Sonomicrometry and pressure transducer cables were externalized to subcutaneous buttons. After 7 days of recovery, hemodynamic and sonomicrometry data were recorded with animals awake and anesthetized.ResultsHemodynamic parameters did not differ between groups. Tricuspid annular area contraction decreased with anesthesia (16.4% ± 4.2% vs 11.2% ± 3.2%, P = .047) as did tricuspid annular perimeter contraction (8.1% ± 2.2% vs 5.4% ± 1.7%, P = .050), predominantly due to reduced contraction of the septal annulus (10.5% ± 2.9% vs 7.5% ± 3.5%, P = .019). Tricuspid annular height did not differ between groups. Minimal distance from anterior, posterior, and septal papillary muscle tips to the annular plane did not change with anesthesia. Regional right ventricle free wall contraction was depressed under anesthesia in anterior (16.3% ± 3.1% vs 12.3% ± 2.2%, P = .027) and lateral (14.9% ± 1.3% vs 11.5% ± 2.8%, P = .016) segments, whereas the posterior remained unchanged.ConclusionsGeneral anesthesia did not alter tricuspid annular or subvalvular 3-dimensional geometry but reduced right ventricular contraction and tricuspid annular dynamics.Copyright © 2018 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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